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Expands VisEn鈥檚 Leading Fluorescence Molecular Imaging Agent Portfolio to Enable Breakthrough Readouts of Cathepsin-K Biomarkers in Research and Drug Development

BEDFORD, MA (July 7, 2009)-- VisEn Medical Inc., a leader in fluorescence in vivo imaging from research through medicine, announced today the commercial launch of its new Cat-K FAST鈩� imaging agent for measuring and monitoring Cathepsin K activity associated with disease progression and therapeutic response in vivo. Cathepsin K expression is well known as a key biomarker and therapeutic target in a range of bone-related diseases, including cancer metastasis to bone, as well as in atherosclerosis. The new Cat-K FAST鈩� agent is expected to significantly expand research and enhance drug development in these areas by enabling real time imaging of Cat-K activity.

Cat-K FAST鈩� represents an additional protease-sensing agent developed and commercially launched based on VisEn鈥檚 new FAST (鈥淔luorescent Activatable Sensor Technology鈥�) in vivo agent platform. FAST agents are based on high-performance, activatable smaller molecules that combine biomarker specificity with optimized biocompatibility and pharmacokinetics for precise measurement and monitoring of key disease biomarkers in vivo.

VisEn鈥檚 proprietary fluorescence imaging agents and labels are designed to provide the industry鈥檚 broadest and most robust range of biologically-specific imaging readouts in vivo. VisEn now offers over 25 different fluorescence molecular agents for imaging key disease-associated biologic targets, processes and pathways. VisEn agent brands include ProSense庐, IntegriSense鈩�, AngioSense鈩�, OsteoSense庐 and MMPSense鈩�. VisEn also offers its specialized in vivo agent labeling platforms, including its proprietary VivoTag庐 fluorescence labeling dyes for custom agent development, and its NanoSpark庐 labeling nanoparticles, all designed and optimized specifically for superior biocompatibility, brightness, stability and performance in in vivo imaging. All VisEn agents and labels, including the new Cat-K FAST鈩� agent, are designed for in vivo biomarker quantification using VisEn鈥檚 Fluorescence Molecular Tomography (FMT鈩�) imaging systems, or for general use along with other non-quantitative fluorescence in vivo imaging systems. VisEn agents are also designed to enable in vitro biomarker readouts in cells and tissues using standard fluorescence microscopy and cellular-based imaging systems. With a focus on translational research and results, all of VisEn鈥檚 technologies are designed to generate translational data linking pre-clinical research into clinical medicine.

About VisEn Medical Inc.

VisEn鈥檚 in vivo fluorescence imaging technologies, including its Fluorescence Agent Portfolio and its Fluorescence Molecular Tomography (FMT鈩�) Imaging Systems, provide robust fluorescence molecular imaging performance in identifying, characterizing and quantifying ranges of disease biomarkers and therapeutic efficacy in vivo. VisEn鈥檚 FMT systems and agents are used by leading research institutions and pharmaceutical companies worldwide in applications including cancer research, inflammation, cardiovascular, skeletal and pulmonary disease. The Company also works with large pharmaceutical partners to design ranges of tailored molecular imaging agents and applications designed for their specific pre-clinical and clinical research areas. Additional information can be found at .