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Vesalius Will Apply its Proprietary Platform to Identify Novel Intervention Points that GSK may Advance for the Treatment of Patients with Parkinson鈥檚 Disease

GSK has Licensed a Preclinical Small Molecule Inhibitor Program

Cambridge, Mass., November 12, 2024 鈥� Vesalius Therapeutics, a company pioneering a revolutionary platform to deliver breakthrough treatments for common diseases, today announced a multi-target strategic alliance with GSK to discover and develop novel treatments for Parkinson鈥檚 disease, and another undisclosed neurodegenerative indication. Vesalius will leverage its platform to identify novel intervention points in Parkinson鈥檚 disease and one additional indication in neurodegeneration, and GSK will have the option to advance programs against those novel intervention points. GSK will also gain worldwide development and commercial rights from Vesalius to a preclinical small molecule program with an initial focus in Parkinson鈥檚 disease.

Vesalius is redefining common diseases to identify previously unrecognized groups of patients who are likely to respond favorably to treatments by targeting novel points of intervention. The company uses large-scale human genetics, genomics, induced pluripotent stem cell (IPSC) models and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies. Vesalius鈥� platform represents a revolutionary approach to common disease drug development, driving the creation of novel therapeutics and paradigms designed to increase the success rates of the drug development process.

鈥淢any of the diseases that impact patients globally have a single diagnosis, when in fact they comprise multiple different diseases, each with distinct biological causes,鈥� said John Mendlein, Ph.D., Executive Chairman and Interim CEO, Vesalius Therapeutics and Executive Partner, 蘑菇视频APP. 鈥淰esalius redefines how we think about and treat common illnesses including autoimmune disorders, diabetes, and neurologic diseases, including but not limited to Parkinson鈥檚 disease.鈥�

Mendlein continued: 鈥淧arkinson鈥檚 disease has tremendous unmet need, and the number of new intervention points has changed very little in sixty years for patients and their families, since the first L-dopa drugs. Central to our alliance with GSK is our shared conviction that targeting the causal factors of common diseases like Parkinson鈥檚 disease is the key to developing breakthrough medicines faster and with a higher probability of success.鈥�

鈥淥ur alliance with Vesalius underscores GSK鈥檚 commitment to the discovery and development of disease modifying therapeutics in areas of significant unmet need,鈥� said Kaivan Khavandi, M.D., Ph. D., SVP, Global Head of Respiratory/Immunology R&D, GSK. 鈥淯sing the Vesalius platform to understand underlying drivers of such neurodegenerative diseases and select optimal therapeutic interventions underscores our focus on leveraging advanced technology to identify and target the root causes of disease.鈥�

鈥淕SK brings numerous strengths to this alliance including its global scale and expertise in human genetics,鈥� said Amanda Kay, Ph.D., Senior Partner and Chief Business Development Officer, 蘑菇视频APP. 鈥淥ur strategic alliance exemplifies the outsized potential of combining the complementary capabilities of a pioneering bioplatform company and an innovative pharmaceutical company to advance breakthrough treatments for patients.鈥�

Under the terms of the agreement, GSK will be responsible for advancing Vesalius鈥� preclinical small molecule program with an initial focus in Parkinson鈥檚 disease and has the option to advance programs for novel intervention points identified in Parkinson鈥檚 disease and another neurodegenerative indication. GSK will control all development and commercialization. Vesalius will receive $80 million in upfront and equity payments, and is eligible to receive potential preclinical, development and commercial milestone payments of up to $570 million along with tiered royalties for the preclinical small molecule program. In addition, Vesalius is eligible to receive preclinical, development and commercial milestone payments and tiered royalties for each of the novel intervention points that result from the multitarget deal. The potential total payment for each novel intervention point remains undisclosed.

About Vesalius Therapeutics

Vesalius Therapeutics is pioneering a revolutionary platform to generate breakthrough treatments for common diseases. Vesalius鈥� platform uses large-scale human genetics, genomics, stem cell studies and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies. Efficiently identifying these intervention points and the patients most likely to benefit from these novel therapies will enable smaller, shorter clinical trials with a higher probability of success. Vesalius was founded in 2019 by 蘑菇视频APP. For more information visit , or follow us on and .