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Achieves Significant Commercial and Technical Milestones

Engages Thomas Weisel Partners to Advise on Strategic Alternatives

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Helicos BioSciences Corporation (NASDAQ: HLCS) announced today its operating highlights for the quarter ended June 30, 2009 and other recent developments following the filing of its Quarterly Report on Form 10-Q for the period ended June 30, 2009.

鈥淚n the second quarter of 2009, we continued to deploy our Helicos鈩� Genetic Analysis System and to advance our technology. The number of installation sites doubled during the second quarter following the installation of our systems in some of the world鈥檚 most distinguished research sites. We also proudly congratulate the Stanford team for using their HeliScope鈩� Sequencer to publish the first ever single-molecule view of a whole human genome. I am pleased to see Helicos gaining commercial momentum in the marketplace and our technology producing scientific results that distinguish single molecule sequencing,鈥� said Ronald A. Lowy, Helicos Chief Executive Officer.

Helicos鈥檚 unique True Single Molecule Sequencing (tSMS)鈩� technology allows scientists and clinical researchers to accurately sequence and quantitate DNA, including minute amounts of ancient and degraded DNA, without amplification or ligation, eliminating the biases inherent in those techniques, and providing increases in throughput and reductions in cost that enable breakthrough scientific research.

Operational Highlights:

Commercial

To date, Helicos has installed six Helicos鈩� Genetic Analysis Systems at the following sites:

Of these installations, Stanford and the undisclosed biotechnology company represent outright system purchases. As previously disclosed, Broad received its system at no cost in early 2009. Dana Farber, MGH and OICR represent placement installations which have been designated as reference sites for scientific and commercial evaluation. These reference sites will have the opportunity to purchase their system outright at the end of the evaluation period.

In addition, Helicos received a system order from St. Laurent Institute. The site location for this system installation and contractual terms associated with the order are being revised by the parties.

Helicos expects that all of these systems will provide additional revenue from the sale of proprietary reagents and that the results of the system evaluations at the reference sites will lead to additional instrument sales.

The current performance capability and applications of the Helicos鈩� Genetic Analysis Platform have generated significant interest from potential customers worldwide. Helicos鈥檚 quoting activity continues to be enhanced by the new funding opportunities from the National Institutes of Health and the National Science Foundation, released as part of the American Recovery and Reinvestment Act (ARRA). Helicos actively supported customers in the preparation of ARRA grant proposals for research projects that could benefit from the unique features of the Helicos platform.

Recently, Helicos reached an important milestone with a customer鈥檚 publication of 鈥淪ingle Molecule Sequencing of an Individual Human Genome鈥� in Nature Biotechnology. Helicos scientists, as well as collaborators, continue to submit and publish manuscripts in top-tier, peer-reviewed scientific journals in areas of resequencing, gene expression, genome regulation, single-molecule proteomics and technology innovation, demonstrating the value of Helicos鈥檚 tSMS approach.

Technology and Science

Strategic Update:

As previously disclosed in the Company鈥檚 Quarterly Report on Form 10-Q for the period ended June 30, 2009, the Company is actively engaged in discussions with potential strategic partners regarding various strategic alternatives including equity financings and other sources of funding, such as joint ventures or partnerships. Such discussions have involved parties inside and outside of the genetic sequencing space. In connection with this activity, the Company has engaged Thomas Weisel Partners (TWP), a nationally recognized investment bank, to assist the Company with its evaluation and execution of strategic alternatives.

The Company is pursuing various strategies in parallel and may ultimately engage in one or more alternative financings or none at all. The Company鈥檚 failure to raise capital as and when needed would have a material negative impact on its financial condition and would have a material adverse impact on the viability of the Company as a going concern.

About Helicos BioSciences:

Helicos BioSciences is a life science company focused on innovative genetic analysis technologies for the research, drug discovery, and diagnostic markets. Helicos鈥� proprietary True Single Molecule Sequencing, tSMS鈩�, technology allows direct measurement of billions of strands of DNA enabling scientists to perform experiments and ask questions never before possible. Helicos is a recipient of the $1,000 genome grant and committed to providing scientists the tools to unlock the era of genomic medicine. The company鈥檚 corporate headquarters are located at One Kendall Square, Building 700, Cambridge, MA 02139, and its telephone number is (617) 264-1800. For more information, please visit .

Certain statements made in this press release that are not based on historical information are forward-looking statements which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. This press release contains express or implied forward-looking statements relating to, among other things, management's expectations of financial performance, expectations regarding the prospective value of the commercial, system performance and technical and scientific achievements and goals discussed in this press release, estimates of expenses and future revenues and profitability, product development and marketing plans, and management's plans, objectives and strategies. These statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond Helicos' control, which could cause actual results to differ materially from those contemplated in these forward-looking statements. In particular, the risks and uncertainties include, among other things, our ability to sustain and scale our manufacturing capabilities and the commercialization process for the Helicos(TM) Genetic Analysis System; our history of operating losses and ability to achieve profitability; the research and development spending levels of academic, clinical and governmental research institutions and pharmaceutical, biotechnology and agriculture companies who may purchase our Helicos(TM) Genetic Analysis System; our reliance on third-party suppliers; competition; changing technology and customer requirements; our ability to operate in an emerging market; market acceptance of our technology; the length of our sales and implementation cycles; our dependence on large contracts for the sale and implementation of our Helicos(TM) Genetic Analysis System; failure of our technology and products; our ability to maintain customer relationships and contracts; ethical, legal and social concerns surrounding the use of genetic information; our ability to retain our personnel and hire additional skilled personnel; our ability to manage our growth while operating with limited resources; our ability to control our operating expenses; general economic and business conditions; the outcome of our discussions with St. Laurent Institute regarding revised terms of their order; the outcome of our strategic partnering discussions and pursuit of financing strategies and other financing alternatives; our ability to obtain capital when desired on terms deemed acceptable to us; and the volatility of the market price of our common stock. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Helicos undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise. For additional disclosure regarding these and other risks faced by Helicos, see the disclosure contained in Helicos' public filings with the Securities and Exchange Commission.

Contacts

Investor Relations:

Helicos BioSciences Corporation
Susan Shepard, 617-264-1850